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Atkin SL 2009 The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study.

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The effect of arginine on the recovery of metformin and the competition mechanism are discussed in this paper.

Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA: The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells.

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Legro RS 2011 Effects of atorvastatin on vascular function, inflammation, and androgens in women with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial.

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The most serious potential side effect of metformin use is lactic acidosis; this complication is very rare, and the vast majority of these cases seem to be related to comorbid conditions, such as impaired liver or kidney function, rather than to the metformin itself.

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Sometimes, children and adolescents receive both insulin therapy and Metformin together for treatment of type 2 diabetes.

First, epidemiological studies show a decrease in cancer incidence in metformin-treated patients.

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It is likely that menstrual cyclicity has a complex relationship with other parameters of PCOS; indeed, multiple linear regression modeling indicates that the improvement in menstrual cyclicity correlates independently with changes of total cholesterol level, BMI, and ovarian volume, but not with changes of testosterone.

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What physicians really need to see is evidence regarding how to best motivate adolescents who are overweight to adopt a significant long-term lifestyle change; this is what will likely result in improved patient-oriented outcomes.

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Evidence supporting the use of metformin in the treatment of cancer.

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Concomitant Insulin therapy: When initiating treatment in patients currently receiving insulin, metformin should be started at 500 mg orally once a day and titrated in 500 mg increments weekly.

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There are no data as to the best time start oral therapy; instead, clinicians should take into account other complicating factors including life expectancy, microvascular and macrovascular complications, risk for adverse events related to glucose control, and patient preference, they wrote.

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All authors also declare: (2) No financial relationships with commercial entities that might have an interest in the submitted work; (3) No spouses, partners, or children with relationships with commercial entities that might have an interest in the submitted work; and (4) No non-financial interests that may be relevant to the submitted work.

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